Purine derivatives are the group of compounds that result from the modification or alteration of purine. Adenine, Guanine, Hypoxanthine, Xanthine, Inosine, and Adenosine are purine derivatives that play key roles in the complex process of uric acid production.
How do purines contribute to uric acid production?
Adenine and guanine, which are components of DNA and RNA, undergo metabolic breakdown in the body. Hypoxanthine and xanthine are intermediate purine derivatives formed during this breakdown. These two intermediates are further metabolized, ultimately leading to the formation of uric acid. Inosine and adenosine are purine derivatives from a different part of the pathway, contributing to the intricate series of reactions that result in the production of uric acid.