Probenecid, commonly known as Benemid or Probalan, is a medication used for treating gout. It works by helping the kidneys remove excess uric acid from the body. This medication helps prevent excess uric acid from building up in the joints, reducing pain and inflammation associated with gout attacks.
What is the mechanism of action of probenecid for gout?
Probenecid inhibits a specific transporter in the renal (kidney) tubules, which is responsible for reabsorbing uric acid back into the bloodstream. By blocking this transporter, it increases the amount of urica acid eliminated through urine; reducing concentration in the body and preventing crystalstalization at the joints.